SPRR2D
Description
The SPRR2D (small proline rich protein 2D) is a protein-coding gene located on chromosome 1.
SPRR2D, also known as SPR-2D or Small proline-rich protein II, is a key component of the cornified envelope, a tough, protective layer that forms on the outermost layer of skin cells. This protein starts within the cell's cytoplasm but eventually binds to other membrane proteins through a process called transglutaminase cross-linking. This creates a strong, insoluble structure beneath the cell membrane, contributing to the skin's resilience and barrier function.
SPRR2D is also known as -.
Associated Diseases
- endometrial cancer
- cancer
- skin squamous cell carcinoma
- popliteal pterygium syndrome
- Dowling-Degos disease 1
- dermatitis
- ichthyosis
