SPRR2A
Description
The SPRR2A (small proline rich protein 2A) is a protein-coding gene located on chromosome 1.
Small proline-rich protein 2A is a protein that in humans is encoded by the SPRR2A gene.
SPRR2A is a gut bactericidal protein that selectively kills Gram-positive bacteria by binding to negatively charged lipids on bacterial membranes, leading to bacterial membrane permeabilization and disruption. It specifically binds lipids with negatively charged headgroups, such as phosphatidic acid, phosphatidylserine (PS), cardiolipin (CL), and phosphatidylinositol phosphates, but not to zwitterionic or neutral lipids. SPRR2A is induced by type-2 cytokines in response to helminth infection and is required to protect against helminth-induced bacterial invasion of intestinal tissue. SPRR2A may also be involved in the development of the cornified envelope of squamous epithelia, however, further evidence is required to confirm this in vivo.
SPRR2A is also known as -.
