SPIRE2
Description
The SPIRE2 (spire type actin nucleation factor 2) is a protein-coding gene located on chromosome 16.
SPIRE2 is involved in the nucleation of actin filaments and remains associated with the pointed end of the new filament. It plays a role in intracellular vesicle transport along actin fibers, connecting actin cytoskeleton dynamics and intracellular transport. SPIRE2 is essential for asymmetric spindle positioning and asymmetric cell division during meiosis. It is required for proper cleavage furrow formation and polar body extrusion during female germ cell meiosis. Additionally, SPIRE2, along with SPIRE1, promotes the assembly of nuclear actin filaments in response to DNA damage, facilitating the movement of chromatin and repair factors after DNA damage.
SPIRE2 is also known as Spir-2.
