SPICE1
Description
The SPICE1 (spindle and centriole associated protein 1) is a protein-coding gene located on chromosome 3.
SPICE1 plays a crucial role in ensuring accurate cell division by regulating centriole duplication, forming a properly structured spindle, and ensuring that chromosomes align correctly during mitosis.
SPICE1 is also known as CCDC52, SPICE.
Associated Diseases
- colorectal cancer
- hemoglobin E-beta-thalassemia syndrome
- IRIDA syndrome
- diabetes mellitus, permanent neonatal 4
- permanent neonatal diabetes mellitus 1
- hemoglobin D disease
- Rh deficiency syndrome
- hemolytic anemia due to erythrocyte adenosine deaminase overproduction
- sideroblastic anemia 3
- overhydrated hereditary stomatocytosis
- congenital dyserythropoietic anemia type 4
- pentosuria
- X-linked dyserythropoetic anemia with abnormal platelets and neutropenia
