SPICE1

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Description

The SPICE1 (spindle and centriole associated protein 1) is a protein-coding gene located on chromosome 3.

SPICE1 plays a crucial role in ensuring accurate cell division by regulating centriole duplication, forming a properly structured spindle, and ensuring that chromosomes align correctly during mitosis.

SPICE1 is also known as CCDC52, SPICE.

Associated Diseases

• colorectal cancer
• hemoglobin E-beta-thalassemia syndrome
• IRIDA syndrome
• diabetes mellitus, permanent neonatal 4
• permanent neonatal diabetes mellitus 1
• hemoglobin D disease
• Rh deficiency syndrome
• hemolytic anemia due to erythrocyte adenosine deaminase overproduction
• sideroblastic anemia 3
• overhydrated hereditary stomatocytosis
• congenital dyserythropoietic anemia type 4
• pentosuria
• X-linked dyserythropoetic anemia with abnormal platelets and neutropenia