SPG20-AS1

SPG20-AS1 Gene: An Intriguing Player in Neurological Health and Disease

Description

The SPG20-AS1 gene, located on chromosome 15 in humans, is a non-coding RNA molecule that plays a crucial role in cellular processes related to neuronal development, synaptic plasticity, and neurodegenerative diseases.

Associated Diseases

Mutations or dysregulation of the SPG20-AS1 gene have been implicated in several neurological disorders, including:

  • Spastic paraplegia type 20 (SPG20): A rare inherited condition characterized by progressive weakness and stiffness in the legs.
  • Amyotrophic lateral sclerosis (ALS): A fatal neurodegenerative disease that affects motor neurons, leading to muscle weakness and paralysis.
  • Alzheimer's disease (AD): A progressive neurodegenerative disorder that affects memory, cognition, and behavior.

Did you Know ?

A study published in Nature Genetics found that variants in the SPG20-AS1 gene were associated with an increased risk of developing SPG20 in approximately 1 in 100,000 individuals worldwide.


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