SPATA41
## The SPATA41 Gene: A Key Player in Male Infertility
Description
The SPATA41 gene, located on chromosome 11, encodes a protein known as spermatogenesis-associated protein 41. This protein is involved in the process of spermatogenesis, the production of sperm cells in males. SPATA41 is essential for the formation and organization of the sperm head, the genetic blueprint that is transmitted to future generations.
Associated Diseases
Mutations in the SPATA41 gene have been linked to a type of male infertility known as non-obstructive azoospermia (NOA). NOA is characterized by the absence of sperm in the semen, even though the testicles are producing sperm. Mutations in SPATA41 can disrupt the organization and structure of the sperm head, leading to sperm that are unable to fertilize an egg.
Did you Know ?
Approximately 1% of male infertility cases are caused by mutations in the SPATA41 gene. This makes SPATA41 one of the most common genetic causes of NOA.
