SPARCL1

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Description

The SPARCL1 (SPARC like 1) is a protein-coding gene located on chromosome 4.

SPARC-like protein 1 (SPARCL1 or SC1), also known as hevin (short for high endothelial venule protein), is a secreted protein with high structural similarity to SPARC. It interacts with the extracellular matrix to create intermediate states of cell adhesion. Due to its dynamic extracellular roles, being implicated in cancer metastasis and inflammation, it is considered a matricellular protein. In humans hevin is encoded by the SPARCL1 gene.

SPARCL1 is also known as MAST 9, MAST9, PIG33, SC1.

Associated Diseases

• cancer
• gastrointestinal stromal tumor
• inherited lipid metabolism disorder
• breast cancer
• urinary bladder carcinoma
• 46,XX ovotesticular disorder of sex development
• 46,XY complete gonadal dysgenesis
• caudal duplication
• testicular agenesis
• 46,XY sex reversal 3
• mullerian duct anomalies-limb anomalies syndrome