SP100

Description

The SP100 (SP100 nuclear antigen) is a protein-coding gene located on chromosome 2.

SP-100 (Space reactor Prototype) was a U.S. research program for nuclear fission reactors usable as small fission power systems for spacecraft. It was started in 1983 by NASA, the US Department of Energy and other agencies. A reactor was developed with heat pipes transporting the heat to thermoelectric generators. It was cooled with lithium. The project never advanced to flight hardware and was terminated in 1994.

SP100, in conjunction with PML, constitutes a significant component of PML bodies, subnuclear organelles involved in numerous physiological processes, including cell growth, differentiation, and apoptosis. It functions as a transcriptional coactivator for ETS1 and ETS2, according to PubMed:11909962. Under certain circumstances, it can also act as a corepressor of ETS1, preventing its DNA binding, as documented in PubMed:15247905. Through the regulation of ETS1, it may contribute to angiogenesis by controlling endothelial cell motility and invasion. By interacting with the MRN complex, it might be involved in the regulation of telomere elongation. SP100 can also regulate TP53-mediated transcription and, through CASP8AP2, regulate FAS-mediated apoptosis. Additionally, it plays a role in viral infections, including human cytomegalovirus and Epstein-Barr virus, potentially through mechanisms involving chromatin and/or transcriptional regulation. Evidence for these functions can be found in PubMed IDs: 11909962, 14647468, 15247905, 15592518, 15767676, 16177824, 17245429, 21274506, and 21880768.

SP100 is also known as lysp100b.

Associated Diseases

WES Whole Exome Sequencing

Clinical Exome Sequencing