SOX11 : SRY-box transcription factor 11
Description
The SOX11 (SRY-box transcription factor 11) is a protein-coding gene located on chromosome 2.
The SOX11 gene provides instructions for making a protein that is essential for the development of the brain and nerve cells. This protein acts as a transcription factor, controlling the activity of other genes by binding to specific regions of DNA. SOX11 can also influence gene activity through chromatin remodeling, a process that changes how tightly DNA is packaged. When DNA is tightly packed, gene expression is lower, but when it's loosely packed, gene expression is higher. The SOX11 gene's own activity is also regulated through chromatin remodeling by special protein groups called SWI/SNF complexes.
SOX11 acts as a transcriptional activator, turning on genes that are important for development. It can work with other proteins like POU3F2/BRN2 or POU3F1/OCT6 to enhance the activation of genes. SOX11 can also directly activate the TEAD2 gene by binding to its promoter and first intron. SOX11 plays a key role in the survival of developing tissues, working alongside SOX4 and SOX12 to contribute to the formation of organs.
SOX11 is also known as CSS9, IDDMOH, MRD27.
