SOCS7
Description
The SOCS7 (suppressor of cytokine signaling 7) is a protein-coding gene located on chromosome 17.
Suppressor of cytokine signaling 7 is a protein that in humans is encoded by the SOCS7 gene. SOCS7 has been shown to interact with NCK1.
SOCS7 regulates signaling pathways through protein ubiquitination and/or sequestration. It plays a role in insulin signaling and glucose homeostasis by promoting the ubiquitination and degradation of IRS1, a key component of the insulin signaling pathway. SOCS7 also inhibits the signaling of prolactin, growth hormone, and leptin by preventing the activation of STAT3 and STAT5, two transcription factors involved in these signaling pathways. It achieves this inhibition by sequestering STAT3 and STAT5 in the cytoplasm, reducing their ability to bind to DNA and activate gene expression. SOCS7 might be a substrate recognition component of a SCF-like E3 ubiquitin-protein ligase complex, which mediates the ubiquitination and degradation of target proteins.
SOCS7 is also known as NAP4, NCKAP4.
Associated Diseases
- type 2 diabetes mellitus
- type 1 diabetes mellitus
- diabetes mellitus, transient neonatal, 2
- hyperinsulinism due to glucokinase deficiency
- acanthosis nigricans-insulin resistance-muscle cramps-acral enlargement syndrome
- renal cysts and diabetes syndrome
- short stature due to partial GHR deficiency
- male hypergonadotropic hypogonadism-intellectual disability-skeletal anomalies syndrome
- islet cell adenomatosis
- glycogen storage disorder due to hepatic glycogen synthase deficiency
- exercise-induced hyperinsulinism
