SOCS6
Description
The SOCS6 (suppressor of cytokine signaling 6) is a protein-coding gene located on chromosome 18.
Suppressor of cytokine signaling 6 (SOCS6) is a protein encoded by the SOCS6 gene. It contains a SH2 domain and a CIS homolog domain, placing it within the cytokine-induced STAT inhibitor (CIS) protein family, also known as the suppressor of cytokine signaling (SOCS) or STAT-induced STAT inhibitor (SSI) family. CIS family members act as negative regulators of cytokine signaling. The expression of SOCS6 is induced by GM-CSF and EPO in hematopoietic cells. Elevated levels of SOCS6 have been observed in factor-independent chronic myelogenous leukemia (CML) and erythroleukemia (HEL) cell lines.
SOCS6 is a component of a negative feedback system that regulates cytokine signaling. It may be part of an E3 ubiquitin ligase complex, which tags target proteins for degradation. Specifically, SOCS6 regulates KIT degradation by ubiquitinating the phosphorylated receptor.
SOCS6 is also known as CIS-4, CIS4, HSPC060, SOCS-4, SOCS-6, SOCS4, SSI4, STAI4, STATI4.
Associated Diseases
- breast cancer
- permanent neonatal diabetes mellitus-pancreatic and cerebellar agenesis syndrome
- cancer
- Duane retraction syndrome
- in situ carcinoma
