SOCS5
Description
The SOCS5 (suppressor of cytokine signaling 5) is a protein-coding gene located on chromosome 2.
Suppressor of cytokine signaling 5 (SOCS5) is a protein encoded by the SOCS5 gene in humans. It contains a SH2 domain and a SOCS BOX domain, placing it within the suppressor of cytokine signaling (SOCS) family, also known as the STAT-induced STAT inhibitor (SSI) protein family. SOCS family members are known to regulate cytokine signaling negatively. While the specific function of SOCS5 is not fully understood, two alternatively spliced transcript variants encoding the same protein have been identified.
SOCS5 is part of a negative feedback system that regulates cytokine signaling. It acts as a substrate-recognition component in an E3 ubiquitin ligase complex (ECS), which targets proteins for degradation. This process helps control various cellular pathways, including EGF signaling by degrading the EGF receptor, and T-helper cell differentiation by inhibiting IL4 signaling, thus influencing the Th2 phenotype. It also partially inhibits IL6 and LIF signaling.
SOCS5 is also known as CIS6, CISH6, Cish5, SOCS-5.
