SOCS2
Description
The SOCS2 (suppressor of cytokine signaling 2) is a protein-coding gene located on chromosome 12.
SOCS2 is a protein encoded by the SOCS2 gene in humans. It belongs to the STAT-induced STAT inhibitor (SSI) family, also known as suppressor of cytokine signaling (SOCS). SSI family members act as negative regulators of cytokine signaling, with SOCS2 expression inducible by specific cytokines like erythropoietin, GM-CSF, IL10, and interferon-gamma (IFN-gamma). SOCS2 interacts with the cytoplasmic domain of insulin-like growth factor 1 receptor (IGF1R), suggesting involvement in regulating IGF1R-mediated cell signaling. Studies in mice have indicated a regulatory role for SOCS2 in IGF-1-related growth control. SOCS2 has been shown to interact with insulin-like growth factor 1 receptor and erythropoietin receptor. Additionally, it acts as a substrate recognition subunit of a Cullin5 E3 ubiquitin ligase complex. It is under investigation for use in targeted protein degradation.
SOCS2, a member of the SOCS family, plays a crucial role in regulating cytokine signal transduction. It acts as a negative regulator in the growth hormone/IGF1 signaling pathway. SOCS2 is part of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex, which facilitates the ubiquitination and subsequent proteasomal degradation of target proteins.
SOCS2 is also known as CIS2, Cish2, SOCS-2, SSI-2, SSI2, STATI2.
