SNX6

Description

The SNX6 (sorting nexin 6) is a protein-coding gene located on chromosome 14.

Sorting Nexin 6, also known as SNX6, is a well-conserved membrane-associated protein belonging to the sorting nexin family and is a component of the retromer complex. The protein contains a coiled-coil domain at its C terminus and a PX domain at its N terminus. Binding to PIM1 causes translocation to the nucleus. SNX6 has been shown to associate with TRAF4.

SNX6 is involved in various stages of intracellular trafficking, interacting with membrane lipids like phosphatidylinositol 3,4-bisphosphate and/or phosphatidylinositol 4,5-bisphosphate. It is a component of the retromer SNX-BAR subcomplex, which mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. SNX6 contributes to the formation of transport carriers by deforming the donor membrane into a tubular profile called endosome-to-TGN transport carrier (ETC). It does not exhibit in vitro vesicle-to-membrane remodeling activity. SNX6 participates in retrograde endosome-to-TGN transport of the lysosomal enzyme receptor IGF2R and may function as a link between transport vesicles and dynactin. It negatively regulates retrograde transport of BACE1 from the cell surface to the TGN. SNX6 plays a role in E-cadherin sorting and degradation by inhibiting PIP5K1C isoform 3-mediated E-cadherin degradation. In association with GIT1, it is involved in EGFR degradation. SNX6 promotes lysosomal degradation of CDKN1B and may contribute to transcription regulation.

SNX6 is also known as MSTP010, TFAF2.

Associated Diseases

WES Whole Exome Sequencing