SNTG1
Description
The SNTG1 (syntrophin gamma 1) is a protein-coding gene located on chromosome 8.
Gamma-1-syntrophin is a protein encoded by the SNTG1 gene in humans. It belongs to the syntrophin family, which are cytoplasmic peripheral membrane proteins. These proteins typically have two pleckstrin homology (PH) domains, a PDZ domain located within the first PH domain, and a C-terminal domain responsible for binding to dystrophin. SNTG1 is specifically expressed in the brain. While transcript variants have been identified, their full-length nature remains unclear.
Gamma-1-syntrophin acts as an adapter protein, influencing the location of various proteins within cells. It likely connects receptors to the cell's structural framework, the actin cytoskeleton, and the dystrophin glycoprotein complex. Additionally, it might play a role in controlling the placement of diacylglycerol kinase-zeta, ensuring rapid inactivation of diacylglycerol following receptor activation.
SNTG1 is also known as G1SYN, SYN4.
Associated Diseases
- substance abuse
- multiple sclerosis
- Alzheimer disease
- Parkinson disease
- lysosomal storage disease
- systemic lupus erythematosus
- cryopyrin-associated periodic syndrome
