SNRPD2
Description
The SNRPD2 (small nuclear ribonucleoprotein D2 polypeptide) is a protein-coding gene located on chromosome 19.
Small nuclear ribonucleoprotein Sm D2 is a protein that in humans is encoded by the SNRPD2 gene. It belongs to the small nuclear ribonucleoprotein core protein family, and is required for pre-mRNA splicing and small nuclear ribonucleoprotein biogenesis. Alternative splicing occurs at this locus and two transcript variants encoding the same protein have been identified.
== Interactions == Small nuclear ribonucleoprotein D2 has been shown to interact with DDX20, Small nuclear ribonucleoprotein D1, Small nuclear ribonucleoprotein polypeptide F, CDC5L and SMN1.
SNRPD2, also known as Sm-D2 or snRNP core protein D2, plays a crucial role in pre-mRNA splicing. It is a core component of the spliceosomal U1, U2, U4, and U5 small nuclear ribonucleoproteins (snRNPs), which are the building blocks of the spliceosome. SNRPD2 is found in both the pre-catalytic spliceosome B complex and the activated spliceosome C complexes. As part of the minor spliceosome, it participates in splicing U12-type introns in pre-mRNAs.
SNRPD2 is also known as SMD2, SNRPD1, Sm-D2.
