SNHG17
Unveiling snhg17: A Gene with a Surprising Role in Health and Disease
Description
snhg17 (small nucleolar RNA host gene 17) is a non-coding RNA gene located on chromosome 17p13.1. It produces a long non-coding RNA (lncRNA) molecule that plays crucial roles in various cellular processes, including gene regulation, cell cycle progression, and differentiation.
Associated Diseases
Dysregulation of snhg17 has been linked to several human diseases, including:
- Cancer: snhg17 overexpression has been found in various cancers, including breast, lung, and colon cancer. It promotes tumor growth, invasion, and metastasis by altering gene expression and disrupting cell signaling pathways.
- Cardiovascular disease: Reduced snhg17 expression has been associated with coronary artery disease and heart failure. It regulates the expression of genes involved in lipid metabolism and inflammation.
- Neurological disorders: Mutations in snhg17 have been linked to amyotrophic lateral sclerosis (ALS) and frontotemporal dementia. It affects neuronal function and may contribute to neurodegeneration.
Did you Know ?
According to a recent study, patients with high levels of snhg17 in their breast tumors had a 40% higher risk of recurrence and a 60% higher risk of death compared to patients with low levels.
