SNHG11
The snhg11 Gene: A Complex Player in Health and Disease
Description
The snhg11 gene is a long non-coding RNA (lncRNA) located on chromosome 11 in humans. LncRNAs are a class of RNA molecules that do not code for proteins but play crucial regulatory roles in gene expression and cellular processes.
snhg11 is a highly conserved gene across species, indicating its importance in fundamental biological functions. It is expressed in various tissues and organs, including the brain, heart, liver, and kidneys. Its expression is regulated by a complex interplay of transcription factors and epigenetic modifications.
Associated Diseases
Aberrant expression of snhg11 has been implicated in the pathogenesis of several diseases, including:
- Cancer: snhg11 overexpression has been observed in various cancers, such as breast, lung, and gastric cancer. It promotes tumor growth, metastasis, and resistance to therapy.
- Neurodegenerative diseases: Reduced snhg11 expression is associated with Alzheimer‘s disease and Parkinson‘s disease. It may play a role in neuronal function and protection against neurotoxicity.
- Cardiovascular diseases: snhg11 regulates vascular inflammation and endothelial cell function. Dysregulated snhg11 expression has been linked to atherosclerosis and heart failure.
- Inflammatory diseases: snhg11 modulates immune responses and inflammation. Its expression is altered in autoimmune diseases such as lupus and rheumatoid arthritis.
Did you Know ?
- Overexpression of snhg11 is found in over 60% of breast cancer cases. This high prevalence highlights the potential significance of snhg11 as a therapeutic target for breast cancer.
