SNCAIP

The SNCAIP Gene: A Vital Player in Neurological Health

Description

The SNCAIP gene encodes the alpha-synuclein interacting protein, a crucial protein involved in neuronal function. It plays a significant role in regulating synaptic transmission, the communication process between neurons. Dysregulation of SNCAIP has been linked to several neurodegenerative disorders, highlighting its importance in maintaining neuronal health.

Associated Diseases

Mutations or malfunctions in the SNCAIP gene have been associated with various neurological conditions, including:

• Parkinson‘s disease: SNCAIP mutations increase the risk of developing Parkinson‘s disease, a movement disorder characterized by tremors, rigidity, and impaired balance.
• Dementia with Lewy bodies (DLB): DLB is a neurodegenerative disorder that shares some clinical features with Parkinson‘s disease. SNCAIP dysfunction is believed to contribute to the development of DLB.
• Multiple system atrophy (MSA): MSA is a rare neurological disorder that affects the autonomic nervous system, motor control, and cognitive function. Mutations in SNCAIP have been found in some MSA cases.

Did you Know ?

• Individuals with certain SNCAIP mutations have an approximately 70% increased risk of developing Parkinson‘s disease compared to those without the mutations.