SNAPC1
Description
The SNAPC1 (small nuclear RNA activating complex polypeptide 1) is a protein-coding gene located on chromosome 14.
SNAPC1 (snRNA-activating protein complex subunit 1) is a protein encoded by the SNAPC1 gene in humans. It interacts with other proteins, including SNAPC4, SNAPC3, and the Retinoblastoma protein.
SNAPC1 is a subunit of the SNAPc complex, which is essential for the transcription of both RNA polymerase II and III small nuclear RNA genes. SNAPC1 binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element found in these genes. It then recruits TBP and BRF2 to the U6 snRNA TATA box, facilitating transcription initiation.
SNAPC1 is also known as PTFgamma, SNAP43.
