SMURF1
Description
The SMURF1 (SMAD specific E3 ubiquitin protein ligase 1) is a protein-coding gene located on chromosome 7.
SMURF1 is an enzyme encoded by the SMURF1 gene in humans. It is a ubiquitin ligase specific for receptor-regulated SMAD proteins in the BMP pathway. SMURF1 plays a role in embryonic pattern formation and is involved in the inhibition of HIV-1 replication. Research in breast cancer has shown a relationship between SMURF1 and ER alpha, suggesting that SMURF1 may influence breast cancer growth.
SMURF1 acts as a negative regulator of the BMP signaling pathway by mediating the ubiquitination and degradation of SMAD1 and SMAD5, two receptor-regulated SMADs specific for this pathway. It also promotes the ubiquitination and degradation of TRAF family members, RHOA, and MAVS. SMURF1 antagonizes TGF-beta signaling by ubiquitinating TGFBR1, leading to its degradation. It plays a role in dendrite formation by melanocytes.
SMURF1 is also known as -.
