SMCR5
Description
The SMCR5 (Smith-Magenis syndrome chromosome region, candidate 5) is a ncRNA gene located on chromosome 17.
SMCR5 is a gene that encodes a protein involved in protein translocation, specifically the docking of the signal recognition particle (SRP) to the endoplasmic reticulum (ER) membrane.
SMCR5, also known as the "signal recognition particle (SRP) receptor subunit alpha", is a vital component of the protein translocation machinery. It acts as a docking site for the SRP, which escorts nascent polypeptide chains to the endoplasmic reticulum (ER) membrane. This interaction initiates the transfer of the polypeptide chain across the ER membrane, ensuring proper protein folding and localization. Mutations in SMCR5 can disrupt this process, leading to a range of cellular dysfunctions.
SMCR5 is also known as NCRNA00034.
