SMAD7
Description
SMAD7, also known as Mothers Against Decapentaplegic homolog 7, is a crucial inhibitory protein that plays a pivotal role in modulating the transforming growth factor-beta (TGF-β) signaling pathway. TGF-β is a versatile cytokine that regulates a wide array of cellular processes, including cell growth, differentiation, apoptosis, and immune responses. SMAD7 acts as a negative regulator of TGF-β signaling by directly interacting with the activated TGF-β receptors and preventing the phosphorylation and nuclear translocation of downstream SMAD proteins, effectively inhibiting TGF-β-mediated gene expression. This intricate interplay between SMAD7 and TGF-β signaling is crucial for maintaining cellular homeostasis and preventing aberrant cell growth and development.
Associated Diseases
- Cancer (e.g., colorectal, breast, lung, pancreatic)
- Fibrosis (e.g., liver, kidney, lung)
- Inflammatory bowel disease
- Immune disorders
- Developmental abnormalities
Did you know?
SMAD7 expression is often dysregulated in various diseases, highlighting its potential as a therapeutic target.
