SMAD1-AS1
Description
The SMAD1-AS1 (SMAD1 antisense RNA 1) is a ncRNA gene located on chromosome 4.
SMAD1-AS1 is a long non-coding RNA (lncRNA) that acts as a regulator of SMAD1 expression. SMAD1 is a crucial protein involved in the TGF-β signaling pathway, which plays a vital role in various cellular processes, including cell growth, differentiation, and immune responses. Studies have shown that SMAD1-AS1 can affect the levels of SMAD1 protein by interacting with microRNAs (miRNAs), which are small RNA molecules that can regulate gene expression. SMAD1-AS1 may act as a sponge for certain miRNAs, preventing them from binding to and suppressing SMAD1 mRNA. This interaction leads to increased levels of SMAD1 protein, potentially enhancing TGF-β signaling. The dysregulation of SMAD1-AS1 has been associated with cancer development, suggesting its potential role in disease progression.
SMAD1-AS1 is a long non-coding RNA (lncRNA) that has been shown to play a role in regulating the expression of SMAD1, a key component of the transforming growth factor-beta (TGF-β) signaling pathway. Studies have suggested that SMAD1-AS1 may act as a molecular sponge for microRNAs (miRNAs), preventing them from binding to and suppressing their target mRNAs, including SMAD1. This interaction can lead to increased levels of SMAD1 protein and enhanced TGF-β signaling. SMAD1-AS1 has also been implicated in various biological processes, including cell proliferation, differentiation, and apoptosis, and its dysregulation has been linked to cancer development. Further research is needed to fully understand the mechanisms and functional significance of SMAD1-AS1 in these contexts.
SMAD1-AS1 is also known as -.
