SLX1A-SULT1A3
Description
The SLX1A-SULT1A3 (SLX1A-SULT1A3 readthrough (NMD candidate)) is a ncRNA gene located on chromosome 16.
The SLX1A-SULT1A3 gene is a human gene that encodes a protein that functions as a scaffold protein in the sulfotransferase complex. This complex plays a vital role in the transfer of sulfate groups from PAPS to acceptor molecules, a process crucial for detoxification, hormone signaling, and enzyme activity regulation.
The SLX1A-SULT1A3 gene is involved in the regulation of sulfotransferase activity, which plays a crucial role in the metabolism of steroids, drugs, and other compounds. This gene encodes a protein that forms a complex with other proteins, including SLX1A, to function as a scaffold for the assembly of the sulfotransferase complex. The complex is responsible for the transfer of a sulfate group from a donor molecule, 3'-phosphoadenosine 5'-phosphosulfate (PAPS), to an acceptor molecule. This sulfation process is essential for various cellular functions, including detoxification, hormone signaling, and the regulation of enzyme activity.
SLX1A-SULT1A3 is also known as HAST3, M-PST, ST1A3, STM, SULT1A3, TL-PST.
Associated Diseases
- acute kidney failure
- type 2 diabetes mellitus
- graft versus host disease
- achalasia-alacrima syndrome
- thrombotic disease
