SLIRP
Description
The SLIRP (SRA stem-loop interacting RNA binding protein) is a protein-coding gene located on chromosome 14.
SLIRP is an RNA-binding protein that functions as a corepressor for nuclear receptors. It achieves this by binding to the SRA RNA, suppressing its coactivation of nuclear receptors. SLIRP specifically interacts with the STR7 loop of the SRA RNA. Additionally, it has the capability to inhibit transactivation mediated by glucocorticoid (GR), androgen (AR), thyroid (TR), and vitamin D receptors (VDR).
SLIRP is also known as C14orf156, DC50, PD04872.
Associated Diseases
- mitochondrial encephalomyopathy
- male infertility with teratozoospermia due to single gene mutation
- spermatogenic failure 65
- spermatogenic failure 72
- spermatogenic failure 46
- spermatogenic failure 27
- spermatogenic failure 18
- spermatogenic failure 42
- spermatogenic failure 49
- spermatogenic failure 45
- spermatogenic failure 19
- spermatogenic failure 43
- spermatogenic failure 51
- spermatogenic failure, X-linked, 3
- spermatogenic failure 39
- spermatogenic failure 40
- spermatogenic failure 47
- spermatogenic failure 24
- spermatogenic failure 41
- spermatogenic failure 10
- spermatogenic failure 11
- spermatogenic failure 20
