SLCO4A1
Description
The SLCO4A1 (solute carrier organic anion transporter family member 4A1) is a protein-coding gene located on chromosome 20.
SLCO4A1 is a protein that is encoded by the SLCO4A1 gene in humans. It is a member of the solute carrier organic anion transporter family.
SLCO4A1 is an organic anion antiporter with broad substrate specificity. It transports a range of molecules, including thyroid hormones (T3, T4, rT3), conjugated steroids (estrone 3-sulfate, estradiol 17-beta glucuronide), bile acids (taurocholate), and prostanoids (prostaglandin E2). This transport is likely tissue-specific. SLCO4A1 may be involved in the uptake of metabolites from the circulation into organs like the kidney, liver, and placenta. It might be responsible for the selective transport of thyroid hormones and estrogens across the placental microvillous membrane, coupled to an outward glutamate gradient. The precise transport mechanism, electrogenicity, and tissue-specific counterions remain to be determined.
SLCO4A1 is also known as OATP-E, OATP1, OATP4A1, OATPE, OATPRP1, POAT, SLC21A12.
