SLCO1C1
Description
The SLCO1C1 (solute carrier organic anion transporter family member 1C1) is a protein-coding gene located on chromosome 12.
Organic anion transporting polypeptides (OATPs), members of the Solute Carrier Family (SLC), are membrane transport proteins that mediate the transport of mainly organic anions across the cell membrane. OATPs catalyze the Na+-independent facilitated transport of fairly large amphipathic organic anions, such as bromosulfobromophthalein, prostaglandins, conjugated and unconjugated bile acids, steroid conjugates, thyroid hormones, anionic oligopeptides, drugs, toxins, and other xenobiotics. They are expressed in many tissues on basolateral and apical membranes, transporting anions, as well as neutral and even cationic compounds. They also transport an extremely diverse range of drug compounds, including anti-cancer, antibiotic, lipid-lowering, and anti-diabetic drugs, as well as toxins and poisons.
SLCO1C1 mediates the transport of thyroid hormones across the blood-brain barrier and into glia and neuronal cells in the brain. It transports L-thyroxine (T4), L-thyroxine sulfate (T4S), and 3,3',5'-triiodo-L-thyronine (reverse T3, rT3) with high affinity at the plasma membrane. SLCO1C1 regulates T4 levels in different brain regions by transporting T4 and acting as an export pump for T4S, which is a source of T4 after hydrolysis by local sulfatases. It also increases the access of these substrates to intracellular sites where they are metabolized by the deiodinases. Other potential substrates, such as triiodothyronine (T3), 17-beta-glucuronosyl estradiol (17beta-estradiol 17-O-(beta-D-glucuronate)), estrone-3-sulfate (E1S) and sulfobromophthalein (BSP) are transported with much lower efficiency. SLCO1C1 transports T4 and E1S in a pH-insensitive manner.
SLCO1C1 is also known as OATP-F, OATP-RP5, OATP1, OATP14, OATP1C1, OATPF, OATPRP5, SLC21A14.
