SLCO1B7
Description
The SLCO1B7 (solute carrier organic anion transporter family member 1B7 (putative)) is a pseudo gene located on chromosome 12.
SLCO1B7 is a gene that encodes a protein known as the organic anion transporting polypeptide 1B7. This protein is primarily found in the liver, where it facilitates the uptake of various compounds, including bile acids, steroid hormones, and drugs, into liver cells. This uptake process is essential for the metabolism, detoxification, and elimination of these compounds from the body. Genetic variations in SLCO1B7 have been associated with differences in drug metabolism and response.
SLCO1B7, also known as the organic anion transporting polypeptide 1B7, plays a crucial role in the uptake of various substances, including bile acids, steroid hormones, and drugs, into the liver. It is primarily expressed in the liver and is responsible for the transport of these compounds across the sinusoidal membrane of hepatocytes. By mediating the uptake of these substances, SLCO1B7 contributes to their metabolism, detoxification, and elimination from the body. Genetic variations in SLCO1B7 have been linked to alterations in drug disposition and response, highlighting its significance in pharmacogenetics.
SLCO1B7 is also known as LST-3, LST-3TM12, LST3, OATP1B7, SLC21A21.
