SLC9B2

---

Description

The SLC9B2 (solute carrier family 9 member B2) is a protein-coding gene located on chromosome 4.

SLC9B2, or solute carrier family 9, subfamily B (NHA2, cation proton antiporter 2), member 2, is a protein involved in maintaining sodium and proton gradients across cell membranes. This protein plays a crucial role in processes like energy production, signal transduction, and drug efflux. It converts the proton motive force generated by the respiratory chain or the F1F0 mitochondrial ATPase into sodium gradients that drive other energy-requiring activities.

SLC9B2 is an electroneutral Na(+) Li(+)/H(+) antiporter that exchanges Na(+) or Li(+) for external protons across the membrane. It utilizes the proton gradient/membrane potential to extrude sodium, contributing to intracellular pH and sodium homeostasis. SLC9B2 also mediates Na(+)/Li(+) antiporter activity in the kidney and may play a role in renal tubular function and blood pressure homeostasis. In beta-cells, SLC9B2 is important for insulin secretion and clathrin-mediated endocytosis. It is also involved in sperm motility and fertility, but its role in osteoclast differentiation remains controversial. SLC9B2 forms a homodimer, and dimerization is essential for its activity. Lipids contribute to the stabilization of the dimerization subdomain.

SLC9B2 is also known as NHA2, NHE10, NHEDC2.

Associated Diseases

• type 2 diabetes mellitus
• multiple sclerosis
• Alzheimer disease
• lysosomal storage disease
• Parkinson disease
• exercise-induced hyperinsulinism
• hyperinsulinemic hypoglycemia, familial, 2
• hyperinsulinism due to INSR deficiency
• hyperinsulinemic hypoglycemia, familial, 1
• glycogen storage disorder due to hepatic glycogen synthase deficiency
• hyperinsulinism due to glucokinase deficiency