SLC6A2
The SLC6A2 Gene: Unlocking the Secrets of Neurotransmitter Transport
Description
The SLC6A2 gene, also known as the norepinephrine transporter gene, plays a crucial role in the regulation of neurotransmission in the brain. It encodes a protein that transports norepinephrine (noradrenaline), a neurotransmitter essential for mood, cognition, and memory, back into the presynaptic neuron after it has been released into the synaptic cleft.
Associated Diseases
Mutations in the SLC6A2 gene have been linked to several neuropsychiatric disorders, including:
- Attention deficit hyperactivity disorder (ADHD): Studies have found an association between certain variations in the SLC6A2 gene and the risk of ADHD.
- Major depressive disorder (MDD): Alterations in SLC6A2 expression or function have been implicated in the pathophysiology of MDD.
- Bipolar disorder: Research suggests that SLC6A2 polymorphisms may contribute to the genetic susceptibility to bipolar disorder.
- Schizophrenia: The SLC6A2 gene has been found to be involved in the regulation of dopamine neurotransmission, which is dysregulated in schizophrenia.
Did you Know ?
Approximately 5-10% of the population carries a variation in the SLC6A2 gene that affects norepinephrine transport. These variations can influence an individual‘s susceptibility to neuropsychiatric disorders.
