SLC5A10

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Description

The SLC5A10 (solute carrier family 5 member 10) is a protein-coding gene located on chromosome 17.

Isoform 1: This protein functions as an electrogenic sodium-coupled sugar symporter, actively transporting D-mannose or D-fructose across the plasma membrane. The transport occurs with a 1:1 ratio of sodium to sugar. The driving force for this transport is the transmembrane sodium electrochemical gradient maintained by the sodium-potassium pump. This transporter exhibits a strict substrate specificity, recognizing only sugars with a pyranose ring and an axial hydroxyl group on carbon 2. It is believed to have evolved to facilitate the reabsorption of D-mannose in the kidneys, as D-mannose is a crucial component of glycoprotein oligosaccharide chains. This protein also contributes to the reabsorption of dietary D-fructose from the glomerular filtrate across the brush border of the kidney.

SLC5A10 is also known as SGLT-5, SGLT5.

Associated Diseases

• familial idiopathic steroid-resistant nephrotic syndrome
• CIDEC-related familial partial lipodystrophy
• LIPE-related familial partial lipodystrophy
• glycogen storage disease VI
• PLIN1-related familial partial lipodystrophy
• acquired partial lipodystrophy
• neonatal intrahepatic cholestasis due to citrin deficiency
• carnitine palmitoyl transferase II deficiency, severe infantile form
• congenital nephrotic syndrome, Finnish type
• pentosuria
• AKT2-related familial partial lipodystrophy
• cirrhosis, familial
• Dent disease type 2
• PPARG-related familial partial lipodystrophy
• carnitine palmitoyl transferase 1A deficiency
• familial partial lipodystrophy, Kobberling type
• familial partial lipodystrophy, Dunnigan type