SLC5A10
Description
The SLC5A10 (solute carrier family 5 member 10) is a protein-coding gene located on chromosome 17.
Isoform 1: This protein functions as an electrogenic sodium-coupled sugar symporter, actively transporting D-mannose or D-fructose across the plasma membrane. The transport occurs with a 1:1 ratio of sodium to sugar. The driving force for this transport is the transmembrane sodium electrochemical gradient maintained by the sodium-potassium pump. This transporter exhibits a strict substrate specificity, recognizing only sugars with a pyranose ring and an axial hydroxyl group on carbon 2. It is believed to have evolved to facilitate the reabsorption of D-mannose in the kidneys, as D-mannose is a crucial component of glycoprotein oligosaccharide chains. This protein also contributes to the reabsorption of dietary D-fructose from the glomerular filtrate across the brush border of the kidney.
SLC5A10 is also known as SGLT-5, SGLT5.
Associated Diseases
- familial idiopathic steroid-resistant nephrotic syndrome
- CIDEC-related familial partial lipodystrophy
- LIPE-related familial partial lipodystrophy
- glycogen storage disease VI
- PLIN1-related familial partial lipodystrophy
- acquired partial lipodystrophy
- neonatal intrahepatic cholestasis due to citrin deficiency
- carnitine palmitoyl transferase II deficiency, severe infantile form
- congenital nephrotic syndrome, Finnish type
- pentosuria
- AKT2-related familial partial lipodystrophy
- cirrhosis, familial
- Dent disease type 2
- PPARG-related familial partial lipodystrophy
- carnitine palmitoyl transferase 1A deficiency
- familial partial lipodystrophy, Kobberling type
- familial partial lipodystrophy, Dunnigan type
