SLC4A7
Description
The SLC4A7 (solute carrier family 4 member 7) is a protein-coding gene located on chromosome 3.
Sodium bicarbonate cotransporter 3 is a protein which in humans is encoded by the SLC4A7 gene.
SLC4A7 encodes an electroneutral sodium- and bicarbonate-dependent cotransporter with a 1:1 stoichiometry of Na+ to HCO3-. This protein mediates sodium-dependent bicarbonate transport, which is crucial for pH recovery after acid exposure and for regulating pH in the duodenum and vascular smooth muscle cells. It is also essential for macrophage acidification, mediating bicarbonate import into the cytoplasm during phagocytosis, which is important for acid extrusion and maintaining cytoplasmic pH. Furthermore, SLC4A7 provides cellular bicarbonate for de novo purine and pyrimidine synthesis and plays a key role in de novo nucleotide synthesis downstream of mTORC1 signaling in proliferating cells. These functions are supported by evidence from various studies including UniProtKB:Q8BTY2 and PubMed:10347222, 12403779, 14578046, 14736710, 29779931, 35772404.
SLC4A7 is also known as NBC2, NBC3, NBCN1, SBC2, SLC4A6.
