SLC39A10
Description
The SLC39A10 (solute carrier family 39 member 10) is a protein-coding gene located on chromosome 2.
Zinc transporter ZIP10, also known as solute carrier family 39 member 10, is a protein that in humans is encoded by the SLC39A10 gene. ZIP10 belongs to a subfamily of proteins that show structural characteristics of zinc transporters, and have 14 members in the human genome: ZIP1, ZIP2, ZIP3, ZIP4, ZIP5, ZIP6, ZIP7, ZIP8, ZIP9, ZIP10, ZIP11, ZIP12, ZIP13 and ZIP14.
Zinc-influx transporter. The SLC39A10-SLC39A6 heterodimer mediates cellular zinc uptake to trigger cells to undergo epithelial-to-mesenchymal transition (EMT). The SLC39A10-SLC39A6 heterodimer plays an essential role in initiating mitosis by importing zinc into cells to initiate a pathway resulting in the onset of mitosis. Important for both mature B-cell maintenance and humoral immune responses. The heterodimer controls NCAM1 phosphorylation and integration into focal adhesion complexes during EMT.
SLC39A10 is also known as LZT-Hs2, ZIP10.
Associated Diseases
- Alzheimer disease
- multiple sclerosis
- Parkinson disease
- lysosomal storage disease
- type 2 diabetes mellitus
- Griscelli syndrome type 3
- uncombable hair syndrome
- oculocutaneous albinism type 3
