SLC2A5

Description

The SLC2A5 (solute carrier family 2 member 5) is a protein-coding gene located on chromosome 1.

SLC2A5 (GLUT5) is a protein encoded by the SLC2A5 gene. It acts as a fructose transporter, facilitating fructose movement from the intestinal lumen into enterocytes. This process occurs through facilitated diffusion, driven by the high concentration of fructose in the intestinal lumen. GLUT5 is also found in skeletal muscle, testis, kidney, fat tissue (adipocytes), and brain.

Fructose malabsorption, also known as dietary fructose intolerance, is a condition characterized by a deficiency of fructose carriers in enterocytes.

Factors such as diabetes mellitus, hypertension, obesity, fructose malabsorption, and inflammation can significantly reduce fructose uptake by GLUT5. However, age-related changes in fructose intake capability are not explained by changes in GLUT5 expression.

The presence of glucose enhances fructose absorption, while sorbitol inhibits it. Fructose absorption through GLUT5 can be studied using intestinal organoids.

SLC2A5 (GLUT5) functions primarily as a fructose transporter, exhibiting low activity with other monosaccharides. It can mediate the uptake of 2-deoxyglucose, though with limited efficiency. SLC2A5 is crucial for fructose absorption in the small intestine. Evidence suggests a role in regulating salt uptake and blood pressure in response to dietary fructose. It may be essential for the development of high blood pressure associated with high fructose intake.

SLC2A5 is also known as GLUT-5, GLUT5.

Associated Diseases

WES Whole Exome Sequencing

Clinical Exome Sequencing