SLC25A24 : solute carrier family 25 member 24
Description
The SLC25A24 (solute carrier family 25 member 24) is a protein-coding gene located on chromosome 1.
The SLC25A24 gene directs the production of a protein belonging to the solute carrier (SLC) family, which transports various compounds across cellular membranes. SLC25A24's protein transports molecules across the inner mitochondrial membrane, the energy-producing centers of cells. It's known as an ATP-Mg/Pi carrier, transporting energy molecules called ATP bound to magnesium (Mg) atoms across the mitochondrial inner membrane in exchange for adding or removing phosphate (P) atoms. This exchange is crucial for normal energy production, molecular metabolism, and protein synthesis within cells.
SLC25A24 acts as an electroneutral antiporter, facilitating the movement of adenyl nucleotides across the inner mitochondrial membrane. Initially recognized for its role in ATP-magnesium/inorganic phosphate exchange, it has broader activity, transporting various adenyl nucleotides. By controlling the adenyl nucleotide pool within mitochondria, SLC25A24 contributes to cellular energy adaptation and indirectly regulates metabolic pathways reliant on adenyl nucleotides. While showing a lower affinity, SLC25A24 can also transport guanyl and pyrimidine nucleotides. Furthermore, SLC25A24 might play a protective role against oxidative stress-induced cell death by buffering calcium levels in the mitochondrial matrix via calcium-phosphate precipitate formation.
SLC25A24 is also known as APC1, SCAMC-1, SCAMC1.
