SLC22A9

Description

The SLC22A9 (solute carrier family 22 member 9) is a protein-coding gene located on chromosome 11.

Solute carrier family 22 member 9 is a protein that in humans is encoded by the SLC22A9 gene.

SLC22A9, also known as Organic anion transporter 7 (OAT7) or Organic anion/short-chain fatty acid exchanger, is a sodium-independent organic anion transporter. It exhibits high specificity for sulfated conjugates of xenobiotics and steroid hormones, such as estrone 3-sulfate (E1S) and dehydroepiandrosterone sulfate (DHEAS). SLC22A9 can transport the statin pravastatin and may contribute to its disposition into the hepatocytes when the function of OATPs is compromised. It is specifically activated by 3 to 5 carbons-containing short-chain fatty acids/SCFAs, including propionate (propanoate), butyrate (butanoate) and valerate (pentanoate). SLC22A9 may operate the exchange of sulfated organic components against short-chain fatty acids/SCFAs, in particular butanoate, at the sinusoidal membrane of hepatocytes.

SLC22A9 is also known as HOAT4, OAT4, OAT7, UST3H, ust3.

Associated Diseases

• glycoprotein storage disease
• neuronal ceroid lipofuscinosis 1
• hemoglobin H disease
• hemoglobin C-beta-thalassemia syndrome
• combined immunodeficiency due to OX40 deficiency
• familial isolated congenital asplenia
• dominant beta-thalassemia
• hemolytic anemia due to diphosphoglycerate mutase deficiency
• hereditary neutrophilia
• hereditary persistence of fetal hemoglobin-beta-thalassemia syndrome
• erythroleukemia, familial, susceptibility to
• beta-thalassemia-X-linked thrombocytopenia syndrome
• colorectal cancer
• hypercoagulability syndrome due to glycosylphosphatidylinositol deficiency
• cryohydrocytosis
• thrombocytopenia, anemia, and myelofibrosis