SLC17A3
Description
The SLC17A3 (solute carrier family 17 member 3) is a protein-coding gene located on chromosome 6.
SLC17A3, also known as Solute carrier family 17 (organic anion transporter), member 3, is a protein that transports urate and other organic anions across cell membranes. The protein is encoded by the SLC17A3 gene. Two isoforms of this protein have been identified, one localized to the plasma membrane and the other to the endoplasmic reticulum. The plasma membrane isoform is a voltage-driven transporter that excretes urate and organic anions from the blood into renal tubule cells. This protein is important for the excretion of uric acid from the body and may also play a role in the metabolism and secretion of other molecules.
This isoform of SLC17A3 transports organic anions across the membrane of renal proximal tubule cells in a voltage-driven, multispecific manner. This transport is directed from the cell into the lumen. This protein is involved in the secretion of urate, the end product of purine metabolism. It also has roles in the metabolism and secretion of other molecules, including estrone sulfate, estradiol-17-beta-glucuronide, ochratoxin A, and drugs such as bumetanide.
SLC17A3 is also known as GOUT4, NPT4, UAQTL4.
