SLC16A2 : solute carrier family 16 member 2
Description
The SLC16A2 (solute carrier family 16 member 2) is a protein-coding gene located on chromosome X.
The SLC16A2 gene provides instructions for making a protein essential for nervous system development. This protein transports the thyroid hormone triiodothyronine (T3) into nerve cells, where it regulates gene expression, affecting nerve cell maturation, migration, and the formation of dendrites and synapses. T3, produced by the thyroid gland, is also involved in the development of many other organs and regulates metabolic processes throughout the body.
SLC16A2 is a transmembrane transporter protein that moves thyroid hormones, primarily T3 and T4, across cell membranes. It works independently of pH or a sodium gradient, facilitating both the uptake and release of these hormones. Its substrates include T3, T4, rT3, and 3,3'-T2, with T3 being the primary target. This transporter is thought to play a critical role in regulating thyroid hormone transport, particularly T3, across the blood-brain barrier.
SLC16A2 is also known as AHDS, DXS128, DXS128E, MCT 7, MCT 8, MCT7, MCT8, MRX22, XPCT.
