SLC15A2
Description
The SLC15A2 (solute carrier family 15 member 2) is a protein-coding gene located on chromosome 3.
SLC15A2, also known as Solute carrier family 15 (H+/peptide transporter), member 2, is a human gene.
SLC15A2 is a proton-coupled amino-acid transporter that transports oligopeptides of 2 to 4 amino acids, particularly dipeptides. It transports neutral and anionic dipeptides with a proton to peptide stoichiometry of 2:1 or 3:1. In the kidney, SLC15A2 is involved in the absorption of circulating di- and tripeptides from the glomerular filtrate. It can also transport beta-lactam antibiotics, such as the aminocephalosporin cefadroxil, and other antiviral and anticancer drugs. SLC15A2 transports the dipeptide-like aminopeptidase inhibitor bestatin and carnosine. It plays a role in innate immunity by promoting the detection of microbial pathogens by NOD-like receptors (NLRs). SLC15A2 mediates the transport of bacterial peptidoglycans across the plasma membrane or, in macrophages, the phagosome membrane, catalyzing the transport of certain bacterial peptidoglycans like muramyl dipeptide (MDP), the NOD2 ligand. SLC15A2 interacts with trypsin through its extracellular domain region.
SLC15A2 is also known as PEPT2.
