SLC15A1
Description
The SLC15A1 (solute carrier family 15 member 1) is a protein-coding gene located on chromosome 13.
SLC15A1, also known as Peptide transporter 1 (PepT 1), is a protein encoded by the SLC15A1 gene in humans. It acts as a solute carrier for oligopeptides, facilitating their reabsorption in the kidneys and absorption in the intestines. This process is proton-dependent, meaning it functions as a cotransporter. SLC15A1 is found on the brush border membrane of intestinal epithelial cells, where it facilitates the uptake of di- and tripeptides from the intestinal lumen into enterocytes. This plays a vital role in the digestion and absorption of dietary proteins. Additionally, SLC15A1 facilitates the absorption of numerous peptidomimetic drugs. Its function in nutrient and drug transport has been studied using intestinal organoids.
SLC15A1 is an electrogenic proton-coupled amino-acid transporter that moves oligopeptides (2-4 amino acids) into cells, favoring dipeptides. It transports both neutral and monovalently charged peptides, with a proton-to-peptide ratio of 1:1 or 2:1. This transporter is essential for the absorption of dietary di- and tripeptides from the small intestine. Additionally, it facilitates the transport of muramyl and N-formylated bacterial dipeptides across epithelial cells, contributing to the mucosal immune system's recognition of pathogenic bacteria.
SLC15A1 is also known as HPECT1, HPEPT1, PEPT1.
