SLC14A2
Description
The SLC14A2 (solute carrier family 14 member 2) is a protein-coding gene located on chromosome 18.
Urea transporter 2 is a protein that in humans is encoded by the SLC14A2 gene. In mammalian cells, urea is the chief end-product of nitrogen catabolism and plays an important role in the urinary concentration mechanism. Thus, the plasma membrane of erythrocytes and some renal epithelial cells exhibit an elevated urea permeability that is mediated by highly selective urea transporters. In mammals, two urea transporters have been identified: the renal tubular urea transporter, UT2 (UT-A), and the erythrocyte urea transporter, UT11 (also called UT-B, coded for by the SLC14A1 gene). SLC14A2 and SLC14A1 constitute solute carrier family 14.
[Isoform 1]: Mediates the transport of urea driven by a concentration gradient across the cell membrane of the renal inner medullary collecting duct which is critical to the urinary concentrating mechanism.
SLC14A2 is also known as HUT2, UT-A2, UT2, UTA, UTR, hUT-A6.
