SLBP
Description
The SLBP (stem-loop histone mRNA binding protein) is a protein-coding gene located on chromosome 4.
SLBP, or stem-loop binding protein, is a protein encoded by the SLBP gene in humans. It is involved in the processing of histone mRNA, which lacks introns and polyadenylation signals. SLBP binds to the stem-loop structure in the 3' UTR of histone mRNA, which is essential for efficient processing. This structure also regulates the transport, translation, and stability of histone mRNA. SLBP expression is regulated during the cell cycle, increasing significantly during the late G1 phase. SLBP is found in humans, C. elegans, D. melanogaster, X. laevis, and sea urchins. The RNA-binding domain (RBD) is highly conserved across species, but the rest of the protein is highly divergent.
SLBP is an RNA-binding protein involved in the processing of histone pre-mRNA. It binds to the stem-loop structure of replication-dependent histone pre-mRNAs, contributing to efficient 3'-end processing by stabilizing the complex between histone pre-mRNA and U7 small nuclear ribonucleoprotein (snRNP) via the histone downstream element (HDE). SLBP plays a key role in targeting mature histone mRNA from the nucleus to the cytoplasm and the translation machinery. Additionally, it stabilizes mature histone mRNA and may be involved in the cell-cycle regulation of histone gene expression. SLBP contributes to the mechanism by which growing oocytes accumulate histone proteins, supporting early embryogenesis. It binds to the 5' side of the stem-loop structure of histone pre-mRNAs.
SLBP is also known as HBP.
