SLAMF7

Description

The SLAMF7 (SLAM family member 7) is a protein-coding gene located on chromosome 1.

SLAMF7 is a protein encoded by the SLAMF7 gene in humans. CD319, also known as SLAMF7, is a reliable marker for identifying normal plasma cells and malignant plasma cells in multiple myeloma. Unlike CD138, the traditional plasma cell marker, CD319/SLAMF7 is more stable and allows for efficient isolation of malignant plasma cells from samples, even those that have been cryopreserved. Elotuzumab is an antibody that targets SLAMF7.

SLAMF7 is a self-ligand receptor belonging to the signaling lymphocytic activation molecule (SLAM) family. SLAM receptors are triggered by cell-cell interactions, influencing the activation and differentiation of a wide range of immune cells. This receptor plays a key role in coordinating both innate and adaptive immune responses. The presence or absence of specific adapter proteins, SH2D1A/SAP and SH2D1B/EAT-2, control the activity of SLAMF7. Isoform 1 of SLAMF7 activates NK cells through an ERK-mediated pathway that is independent of SH2D1A. This isoform also promotes NK cell function through a mechanism reliant on phosphorylated SH2D1B. Downstream signaling involves PLCG1, PLCG2, and PI3K. While heterotypic interactions between NK cells and target cells contribute to activation, homotypic interactions between NK cells can also play a role. However, in the absence of SH2D1B, SLAMF7 inhibits NK cell function. SLAMF7 can also have an inhibitory effect in T cells. It is thought to be involved in lymphocyte adhesion. In LPS-activated monocytes, SLAMF7 negatively regulates the production of pro-inflammatory cytokines. Isoform 3 of SLAMF7 does not mediate NK cell activation. Isoform 1 can bind to SH2D1A when its cytoplasmic tail is phosphorylated in the presence of FYN, but this interaction is weak, and its physiological significance is questionable. SLAMF7 interacts with SH2D1B in NK cells, as well as with ITSM (phosphorylated on Tyr-302), PTPN6/SHP-1, PTPN11/SHP-2, INPP5D/SHIP1, CSK, and FYN.

SLAMF7 is also known as 19A, CD319, CRACC, CS1.

Associated Diseases

WES Whole Exome Sequencing