SKAP2
Description
The SKAP2 (src kinase associated phosphoprotein 2) is a protein-coding gene located on chromosome 7.
SKAP2 is an enzyme encoded by the SKAP2 gene in humans. It belongs to the src family kinases and is similar to SKAP1. As an adaptor protein, SKAP2 is thought to play a crucial role in the src signaling pathway, particularly in macrophages. It inhibits PTK2B/RAFTK activity and regulates alpha-synuclein phosphorylation. It interacts with Signal-regulatory protein alpha and directs integrin-activated cytoskeletal reorganization in macrophages.
SKAP2 might be involved in the adhesion of B-cells and macrophages. In B-cells, it might connect the B-cell receptor (BCR) to integrin activation. It could play a role in the src signaling pathway.
SKAP2 is also known as PRAP, RA70, SAPS, SCAP2, SKAP-HOM, SKAP55R.
