SIRPG
Description
The SIRPG (signal regulatory protein gamma) is a protein-coding gene located on chromosome 20.
Signal-regulatory protein gamma is a protein encoded by the SIRPG gene in humans. It is also known as CD172G. This protein belongs to the signal-regulatory protein (SIRP) family and the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. Different isoforms of SIRPG are produced through alternative splicing.
SIRPG is a probable immunoglobulin-like cell surface receptor. It mediates cell-cell adhesion by binding to CD47. When CD47 on antigen-presenting cells engages SIRPG on T-cells, it enhances antigen-specific T-cell proliferation and costimulates T-cell activation.
SIRPG is also known as CD172g, SIRP-B2, SIRPB2, SIRPgamma, bA77C3.1.
Associated Diseases
- type 1 diabetes mellitus
- cancer
- isolated asymptomatic elevation of creatine phosphokinase
- major depressive disorder
- plasma fibronectin deficiency
- pentosuria
