SIRPB1
Description
The SIRPB1 (signal regulatory protein beta 1) is a protein-coding gene located on chromosome 20.
Signal-regulatory protein beta-1 (SIRPB1), also known as CD172B, is a protein encoded by the SIRPB1 gene in humans. It belongs to the signal-regulatory-protein (SIRP) family and the immunoglobulin superfamily. SIRP family members are transmembrane glycoproteins that act as receptors and are involved in regulating the activity of receptor tyrosine kinases, which are proteins involved in cell signaling. SIRPB1 interacts with TYROBP/DAP12, a protein containing immunoreceptor tyrosine-based activation motifs, and participates in the recruitment of the tyrosine kinase SYK. Alternative splicing generates different versions of this gene's transcript. SIRPB1 has been shown to interact with TYROBP.
This protein acts as a cell surface receptor with an immunoglobulin-like structure, playing a crucial role in regulating the activity of receptor tyrosine kinases, which are proteins involved in cell signaling.
SIRPB1 is also known as CD172b, SIRP-BETA-1.
Associated Diseases
- type 1 diabetes mellitus
- isolated asymptomatic elevation of creatine phosphokinase
- major depressive disorder
- plasma fibronectin deficiency
- pentosuria
- systemic lupus erythematosus
