SIK2
Description
The SIK2 (salt inducible kinase 2) is a protein-coding gene located on chromosome 11.
Serine/threonine-protein kinase SIK2 is an enzyme that in humans is encoded by the SIK2 gene. SNF1LK2 has been shown to interact with CRTC2.
SIK2 is a serine/threonine-protein kinase that plays a role in various biological processes, including fatty acid oxidation, autophagy, immune response, and glucose metabolism. It phosphorylates IRS1 (Ser-794) in insulin-stimulated adipocytes, potentially influencing insulin signal transduction efficiency. SIK2 inhibits CREB activity by phosphorylating and repressing TORCs, the CREB-specific coactivators. It also phosphorylates EP300, inhibiting its histone acetyltransferase activity and regulating the DNA-binding ability of transcription factors like PPARA and MLXIPL. Additionally, SIK2 contributes to thymic T-cell development.
SIK2 is also known as LOH11CR1I, QIK, SIK-2, SNF1LK2.
