SIGLEC7
Description
The SIGLEC7 (sialic acid binding Ig like lectin 7) is a protein-coding gene located on chromosome 19.
Sialic acid-binding Ig-like lectin 7 is a protein encoded by the SIGLEC7 gene in humans. It is also known as CD328.
SIGLEC7 is a cell adhesion molecule that binds to sialic acids on other cells. It prefers alpha-2,3- and alpha-2,6-linked sialic acids and can also bind to disialogangliosides. The binding site can be blocked by interactions with sialic acids on the same cell surface. In the immune system, SIGLEC7 acts as an inhibitory receptor, recruiting phosphatases to dephosphorylate signaling molecules and block signal transduction. This leads to inhibition of natural killer cell cytotoxicity. SIGLEC7 may also play a role in blood cell development, inhibiting differentiation of CD34+ cell precursors and proliferation of leukemic myeloid cells.
SIGLEC7 is also known as AIRM-1, AIRM1, CD328, CDw328, D-siglec, QA79, SIGLEC-7, SIGLEC19P, SIGLECP2, p75, p75/AIRM1.
Associated Diseases
- neutrophil immunodeficiency syndrome
- Miyoshi myopathy
- type 2 diabetes mellitus
- hyper-IgM syndrome type 2
- immunodeficiency, common variable, 4
- cancer
