SIGLEC16
Description
The SIGLEC16 (sialic acid binding Ig like lectin 16) is a protein-coding gene located on chromosome 19.
SIGLEC16 is a human gene that encodes a protein with a potential role in cell adhesion. It is characterized by its ability to bind to sialic acids, suggesting a mechanism for mediating cell-to-cell interactions.
SIGLEC16 is thought to act as an adhesion molecule, facilitating interactions between cells by binding to sialic acids on their surfaces. This sialic-acid dependent binding suggests a role in cell recognition and communication.
SIGLEC16 is also known as SIGLECP16, Siglec-P16.
Associated Diseases
- common variable immunodeficiency
- combined immunodeficiency with skin granulomas
- BENTA disease
- classic Hodgkin lymphoma
- immunodeficiency 18
- isolated agammaglobulinemia
- immunodeficiency 62
- severe combined immunodeficiency due to CTPS1 deficiency
- immunodeficiency, common variable, 14
- severe combined immunodeficiency due to CARD11 deficiency
- immunodeficiency 73c with defective neutrophil chemotaxis and hypogammaglobulinemia
- agammaglobulinemia 10, autosomal dominant
- immunodeficiency 105
- neutropenia, severe congenital, 2, autosomal dominant
- hyper-IgM syndrome type 3
- inborn error of immunity
- immunodeficiency, common variable, 4
- immunodeficiency 99 with hypogammaglobulinemia and autoimmune cytopenias
- immunodeficiency 25
- agammaglobulinemia 7, autosomal recessive
- immunodeficiency due to selective anti-polysaccharide antibody deficiency
