SIGLEC16

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Description

The SIGLEC16 (sialic acid binding Ig like lectin 16) is a protein-coding gene located on chromosome 19.

SIGLEC16 is a human gene that encodes a protein with a potential role in cell adhesion. It is characterized by its ability to bind to sialic acids, suggesting a mechanism for mediating cell-to-cell interactions.

SIGLEC16 is thought to act as an adhesion molecule, facilitating interactions between cells by binding to sialic acids on their surfaces. This sialic-acid dependent binding suggests a role in cell recognition and communication.

SIGLEC16 is also known as SIGLECP16, Siglec-P16.

Associated Diseases

• common variable immunodeficiency
• combined immunodeficiency with skin granulomas
• BENTA disease
• classic Hodgkin lymphoma
• immunodeficiency 18
• isolated agammaglobulinemia
• immunodeficiency 62
• severe combined immunodeficiency due to CTPS1 deficiency
• immunodeficiency, common variable, 14
• severe combined immunodeficiency due to CARD11 deficiency
• immunodeficiency 73c with defective neutrophil chemotaxis and hypogammaglobulinemia
• agammaglobulinemia 10, autosomal dominant
• immunodeficiency 105
• neutropenia, severe congenital, 2, autosomal dominant
• hyper-IgM syndrome type 3
• inborn error of immunity
• immunodeficiency, common variable, 4
• immunodeficiency 99 with hypogammaglobulinemia and autoimmune cytopenias
• immunodeficiency 25
• agammaglobulinemia 7, autosomal recessive
• immunodeficiency due to selective anti-polysaccharide antibody deficiency